No serious harmful effects have been reported with overdose of desogestrel. Serious side effects of combined oral contraceptives containing desogestrel may include venous thromboembolism, arterial thromboembolism, hormone-dependent tumors (e.g., liver tumors, breast cancer), and melasma. Breast discharge, ectopic pregnancies, and aggravation of angioedema may also occur with desogestrel. Uncommon side effects of desogestrel may include vaginal infection, contact lens intolerance, vomiting, hair loss, dysmenorrhea, ovarian cysts, and fatigue, while rare side effects include rash, urticaria, and erythema nodosum. Desogestrel can also cause changes in total, LDL, and HDL cholesterol. In addition, acne and hirsutism are negligible when combined with ethinylestradiol, and this combination can actually be used to treat such symptoms. However, it has also been reported to not adversely affect weight. See also: Etonogestrel § Side effects, and Progestin § Side effectsĬommon side effects of desogestrel may include menstrual irregularities, amenorrhea, headaches, nausea, breast tenderness, and mood changes (e.g., depression), as well as weight gain, acne, and hirsutism. In 2020, the version with ethinylestradiol was the 120th most commonly prescribed medication in the United States, with more than 5 million prescriptions. Desogestrel is marketed widely throughout the world. Along with norethisterone, it is one of the only progestins that is widely available as a progestogen-only "mini pill" for birth control. Desogestrel is sometimes referred to as a "third-generation" progestin. It became available in the United States in 1992. ĭesogestrel was discovered in 1972 and was introduced for medical use in Europe in 1981. The medication is a prodrug of etonogestrel (3-ketodesogestrel) in the body. It has very weak androgenic and glucocorticoid activity and no other important hormonal activity. Desogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. Side effects of desogestrel include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others. The medication is available and used alone or in combination with an estrogen. ![]() It is also used in the treatment of menopausal symptoms in women. ![]() However, low-dose pills may result in more breakthrough bleeding - bleeding or spotting between periods - than higher dose pills.Desogestrel is a progestin medication which is used in birth control pills for women. Women who are sensitive to hormones may benefit from taking a pill that contains a dose of estrogen at the lower end of this range. Most combination birth control pills contain 10 to 35 micrograms of ethinyl estradiol, a kind of estrogen. ![]() In this type of combination birth control pill, the amounts of hormones in active pills vary. In this type of combination birth control pill, each active pill contains the same amounts of estrogen and progestin. Formulations that contain only active pills - eliminating bleeding - also are available.Ĭombination birth control pills are also categorized according to whether the dose of hormones in the active pills stays the same or varies: Bleeding generally occurs only four times a year, during the time when you take the inactive pills. These packs typically contain 84 active pills and seven inactive pills. Bleeding occurs every month when you take the inactive pills. Conventional packs usually contain 21 active pills and seven inactive pills, or 24 active pills and four inactive pills. Combination birth control pills come in different mixtures of active and inactive pills, depending on how often you want to have periods:
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